Investigacion-oculto

CBE-IQFR researcher work in an international collaborative project to watch in real time the diffusion of ligands into enzyme crystals using the state-of-the-art XFEL technology. The article has been published in IUCrJ.

CBE-IQFR researcher work in an international collaborative project to watch in real time the diffusion of ligands into enzyme crystals using the state-of-the-art XFEL technology. The article has been published in IUCrJ (https://journals.iucr.org/m/issues/2021/06/00/mf5055/index.html). From our experiments, we have been able to capture a real time view into the catalytic site of the enzyme beta-lactamase C from Mycobacterium tuberculosis during the binding of the antibiotic ceftriaxone and the inhibitor sulbactam. This demonstrates that XFEL technology can be used as an important tool for biomedicaly relevant research.