Seminario impartido por Lukasz Joachimiak (U. Southwestern)
The microtubule-associated protein tau forms β-sheet-rich amyloids in over 25 neurodegenerative diseases, commonly referred to as tauopathies. Cryogenic electron microscopy has revealed unprecedented molecular insight into the diversity of conformations of tau amyloids observed in tauopathies. It remains unknown how the intrinsically disordered protein tau can adopt different amyloid folds across disease. In this seminar, I will present the results derived from biochemical, structural and computational methods that begin to interpret the logic behind tau misfolding events that can lead to the formation of pathogenic tau species in disease and how molecular chaperones interfere with this process. A deeper understanding of the tau misfolding mechanisms can be used to guide the development of conformation-specific diagnostic and therapeutic approaches tailored toward tauopathies.
Ponente del seminario: Lukasz Joachimiak
Fecha del seminario: 30/06/2023 12:00
Lugar del seminario: Instituto de Química Física Blas Cabrera
