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El IQF celebra el Día Internacional de la Mujer con el documental ¿Puedes darme tres nombres? De esta manera, queremos homenajear a todas las valientes mujeres que desde los años treinta del siglo XX trabajaron en el edificio Rockefeller, desafiando los estereotipos de género de su época e inspirando a las nuevas generaciones de científic@s. La Comisión de Igualdad del IQF tiene el compromiso de trabajar y colaborar con todo el personal del centro para eliminar cualquier forma de discriminación que pueda acaecer en el mismo. En fechas tan señaladas, nos gustaría recordar que la igualdad de género es esencial para el enriquecimiento de los grupos de trabajo, el progreso y el desarrollo, no sólo de la investigación, sino de toda la sociedad en su conjunto.

En sus 90 años de historia, la misión de nuestro instituto ha sido realizar una  investigación de excelencia en fisicoquímica fundamental y aplicada, contribuyendo a la formación de varias generaciones de  científicos del máximo nivel. La visión de nuestro instituto es ser una referencia internacional en investigación multidisciplinar enfocada a resolver los retos actuales de nuestra sociedad en ámbitos de salud, biotecnología, nuevos materiales y medioambiente.

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Seminario: Respiratory Cytochrome c: a Master Pleiotropic Cell Regulator
Miércoles, 1. Junio 2022, 12:00
Contacto Jose Miguel Mancheño Gómez

Over the past decade, evidence has emerged suggesting a much broader role for cytochrome c in the transition of apoptotic cells from life to death.

Over the past decade, evidence has emerged suggesting a much broader role for cytochrome c in the transition of apoptotic cells from life to death. In the lecture, I will show novel mechanistic insights into electron transfer (ET) from cytochrome c1 to cytochrome c1, including gated, long-range ET in aqueous solution. Remarkably, a close contact between cytochrome c1 and cytochrome c is not essential for ET: when proteins are approaching each other, cation exclusion occurs between their active sites, enabling the building of a Gouy-Chapman charge conduit and the long-distance ET through the aqueous solution2. Phosphorylation of cytochrome c not only affects its structure and dynamics3,4, but also shortens the long-distance charge conduit between the partners, strengthens their interaction, and departs it from equilibrium5. In response to DNA damage, cytochrome c escapes from its natural mitochondrial environment and, once in the cytoplasm, binds to Apaf-1 to form a complex—the so-called apoptosome—that triggers caspase activation and further leads to controlled cell dismantlement. Recent work from our group shows that cytochrome c in the cytoplasm also binds to the chaperone 14-3-3e, which is an inhibitor of Apaf-1, to block 14-3-3e-mediated Apaf-1 inhibition, thereby unveiling a novel function for cytochrome c as an indirect activator of caspase-9/3.6,7 Besides such key apoptotic roles of cytochrome c in the cytoplasm, its migration to the nucleus soon after DNA damage—even before caspase cascade activation and apoptosome formation in the cytoplasm—has recently been an exciting discovery.8 Cytochrome c in the nucleus actually targets a variety of well-known histone chaperones involved in chromatin remodeling and DNA damage response.4-6 Our results show that nuclear/nucleolar cytochrome c inhibits the nucleosome (dis)assembly activity of histone chaperones, impairs dephosphorylation events and controls p53-mediated cell cycle arrest during the repair of injured DNA8-10. Histone chaperones do interact with cytochrome c lysine residues through their acidic disordered regions, which are involved in the heterotypic contacts leading to liquid-liquid phase transitions and are responsible for the assembly of nuclear condensates, including heterochromatin.11,12 Altogether, our recent data demonstrate that cytochrome c functions as a master, pleiotropic organellar factor, thereby playing a crucial global role in cell metabolism, both in life and death. 1Pérez-Mejías et al., (2022) Coord Chem Rev 450: 214233; 2Laguna et al., (2018) Nat Comm 9: 5157; 3Moreno-Beltrán et al., (2017) PNAS 114: E3041; 4Guerra-Castellano et al., (2018) PNAS 116: 7955; 5Gomila et al., (2022) Nat Comm under review; 6Elena-Real et al., (2018) Cell Death Dis 9: 365; 7Elena-Real et al., (2021) Plant J 106: 74; 8González-Arzola et al., (2015) PNAS 112: 9908; 9González-Arzola et al., (2017) Nucleic Acids Res 45: 2150; 10Rivero-Rodríguez et al., (2021) Redox Biol 43: 101967; 11González-Arzola et al., (2022) Nat Struct Mol Biol minor revisión; 12González-Arzola et al., (2021) FEBS Open Bio 11: 2418

Fecha del seminario: 01/06/2022 12:00

Lugar del seminario: Salón de Actos

Ponente del seminario: Irene Díaz Moreno

Abstract

 

Localización Salón de actos

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