Vinaora Nivo Slider 3.xVinaora Nivo Slider 3.xVinaora Nivo Slider 3.xVinaora Nivo Slider 3.xVinaora Nivo Slider 3.x

En sus 88 años de historia, la misión de nuestro instituto ha sido realizar una  investigación de excelencia en fisicoquímica fundamental y aplicada, contribuyendo a la formación de varias generaciones de  científicos del máximo nivel. La visión de nuestro instituto es ser una referencia internacional en investigación multidisciplinar enfocada a resolver los retos actuales de nuestra sociedad en ámbitos de salud, biotecnología, nuevos materiales y medioambiente.

Intranet

Hoy

Sin eventos

Próximos eventos

Sin eventos
Noviembre 2019
L M X J V S D
1 2 3
4 5 6 7 8 9 10
11 12 13 14 15 16 17
18 19 20 21 22 23 24
25 26 27 28 29 30

Calendario de eventos

Seminario: Protein amyloid aggregation and its role in the development of neurodegenerative disorders
Miércoles, 6. Noviembre 2019, 12:00
Contacto Jose Miguel Mancheño Gómez

Many neurodegenerative disorders, including Alzheimer´s and Parkinson´s disease, are characterised by the conformational change of normally soluble proteins or peptides into pathological conformers by a process of misfolding

Many neurodegenerative disorders, including Alzheimer´s and Parkinson´s disease, are characterised by the conformational change of normally soluble proteins or peptides into pathological conformers by a process of misfolding and self-assembly that leads to the formation of amyloid aggregates. Recent studies, including ours, on alpha-synuclein, the protein whose aggregation and deposition is associated with a number of neurodegenerative diseases collectively referred to as synucleinopathies, including Parkinson´s disease, have shown that multiple aggregated species can be generated through diverse misfolding pathways during the process of amyloid aggregation, which possess different degrees of neuronal toxicity and infectivity. We are elucidating some of the different mechanisms that lead to alpha-synuclein self-assembly and the formation of structurally different amyloid polymorphs, some of which could be involved in distinct pathologies and/or stages of the development of a particular disease, i.e. in the initial induction of neurotoxicity or in the propagation of pathology. In addition, we have been able to trap and isolate some intermediate oligomeric species with significant biological relevance and determine the structural basis of their toxicity, which can help us to develop rational strategies based on amyloid toxicity for the early detection and treatment of synucleinopathies.

Fecha del seminario: 06/11/2019 12:00

Lugar del seminario: Salón de Actos

Ponente del seminario: Nunilo Cremades

Abstract

Localización Salón de Actos IQFR - Serrano 119