Research
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Pathogens try to escape from our immune system by mutating their proteins. To prevent the bacterium from infecting the cells with a single mutation, the NAIP5 protein of the inflammosome is capable of detecting bacterial flagellin at several sites.
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The notion that strong laser light can intervene and modify the dynamical processes of matter has been demonstrated and exploited both in gas and condensed phases.
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The i-motif is four-stranded DNA structure stabilized by hemiprotonated cytosine base pairs (C:C+). Although this is a very attractive structural motif for the development of devices at a nanometric scale, the requirement of acidic pH for its formation makes the i-motif occurrence in vivo controversial.
Read more: Prevalent sequences in the human genome can form i-motif structures at physiological pH
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Statistics from structural genomics initiatives reveal that around 50-55% of the expressed, non-membrane proteins cannot be purified and therefore structurally characterized due to solubility problems
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Processes catalyzed by enzymes offer numerous advantages over chemical methods although in many occasions the stability of the biocatalysts becomes a serious concern.
Read more: Crystal structure of 2'-Deoxyribosyltransferase from Leishmania mexicana
