Research

Research

PBP2x is an essential transpeptidase in Streptococcus pneumoniae, critical for septal peptidoglycan synthesis during cell division. Recognition of nascent peptidoglycan at an allosteric site located in the PASTA domains of this enzyme predisposes penetration of peptidoglycan into the active site for turnover events.

The IQFR, together with other CSIC Institutes, participates in the European project PARTHENOS. This project aims to develop a research infrastructure in the sector of humanities and favour the integration and interoperability between research infrastructure services.

Structure-function relationships of a novel 2´-deoxyribosyltransferase from the psychrotolerant bacterium Bacillus psychrosaccharolyticus (BpNDT) have been exhaustively studied by biochemical and high resolution crystallographic analyses.

Streptococcus suis is one of the most important pathogens in the porcine industry and an emerging zoonotic agent that infects humans, causing high fatality rates.

Enzybiotics are a novel class of antibacterials, based on the peptidoglycan lysins, which kill rapidly and specifically the bacteria, preventing the appearance of crossed resistances with other pathogens and the microbiota degradation.