A multidisciplinar study published in J. Med. Chem. by IQFR researchers has revealed key structural insights for the regulation of the NCS-1/Ric8a protein/protein interaction with small molecules. This has led to the discovery of a drug-like compound with promissing prospect for fragile X syndrome pharmacotherapy.

A collaborative study published in Nucleic Acids Research by members of IQFR and the Área de Genética-Universidad de Murcia (Unidad Asociada al IQFR) describes a new mechanism for regulated expression of a CRISPR-Cas system in the soil bacterium Myxococcus xanthus

The “chameleonic” peptide LytA239-252 forms a β-hairpin in aqueous solution which is converted into an α-helix in the presence of micelles. We have found that the balance of hydrophobicity <H> and amphipathicity <μH> contributes to helix stability.

Geochemical analyses in a Greenland ice core reveal a significant increase in atmospheric iodine concentrations as a consequence of the raise in human-induced tropospheric ozone and Arctic sea-ice retreat. A multidisciplinar research led by CSIC researchers reconstruct the iodine atmospheric fluxes since the onset of the Industrial Revolution.

The lytic transglycosilase Slt is critical in the cell wall recycling in Pseudomonas aeruginosa, as well in antibiotic resistance. Our structural work results disclose the details of bacterial response mediated by Slt to the b-lactam antibiotic challenge.