Research
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The lytic transglycosilase Slt is critical in the cell wall recycling in Pseudomonas aeruginosa, as well in antibiotic resistance. Our structural work results disclose the details of bacterial response mediated by Slt to the b-lactam antibiotic challenge.
Read more: The molecular mechanism of b-lactam resistance in Pseudomonas aeruginosa disclosed
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We have grown high quality magnetite microcrystals conserving bulk magnetic properties below 20 nm thickness. The observed domain configurations are dictated purely by shape anisotropy thus demonstrating the possibility of designing spin structures in ultrathin, magnetically soft magnetite at will.
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PBP2x is an essential transpeptidase in Streptococcus pneumoniae, critical for septal peptidoglycan synthesis during cell division. Recognition of nascent peptidoglycan at an allosteric site located in the PASTA domains of this enzyme predisposes penetration of peptidoglycan into the active site for turnover events.
Read more: Allosteric Mechanism in essential PBP2x in pneumococcal division
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The IQFR, together with other CSIC Institutes, participates in the European project PARTHENOS. This project aims to develop a research infrastructure in the sector of humanities and favour the integration and interoperability between research infrastructure services.
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Structure-function relationships of a novel 2´-deoxyribosyltransferase from the psychrotolerant bacterium Bacillus psychrosaccharolyticus (BpNDT) have been exhaustively studied by biochemical and high resolution crystallographic analyses.