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In its 88-year story, the mission of our institute has been to carry out excellence research in fundamental and applied physical chemistry, contributing to the scientific training of several generations of researchers at the highest level. Our vision is to be an international reference in multidisciplinary research focused on the resolution of the present challenges of our society in the fields of health, biotechnology, new materials, and environment.

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August 2020
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"Pablo García-Risueño started his work on this subject when doing his PhD at the institute."

 

The problem of the electrostatic potential is almost ubiquituous in chemical and atomic/molecular simulations. In this paper just published at the Journal of Computational Chemistry (and appearing at its front cover), Pablo García-Risueno et al. present an analysis of different methods to calculate the classical electrostatic Hartree potential created by charge distributions. This work may enable more accurate and efficient simulations, helping scientists to tackle many new systems.

 

 

webMetabolic resistance to insecticides is the biggest threat to the continued effectiveness of malaria vector control. In the frame of a transnational research program, we have demonstrated that a single amino acid change in the glutathione-s-transferase confers high levels of DDT resistance in the African mosquito Anopheles funestus.  Interestingly, this metabolic resistance marker perfectly correlates with patterns of DDT resistance across Africa. The x-ray structures of two polymorphic GSTe2 corresponding to those populations presenting an intensified resistance or sensitiveness phenotypes show that the mutation confers resistance by enlarging the GSTe2 DDT-binding cavity leading to increased DDT access and metabolism. This knowledge constitutes a valuable tool for future operational monitoring of insecticide resistance in Africa and allows us to design novel molecules with enhanced insecticide properties.

Reference:

A single mutation in the GSTe2 gene allows tracking of metabolically based insecticide resistance in a major malaria vector

Riveron JM, Yunta C, Ibrahim SS, Djouaka R, Irving H, Menze BD, Ismail HM, Hemingway J, H. Ranson, A. Albert  and C.S. Wondji
Genome Biology 2014, 15:R27 (25 February 2014)

Highlighted at:

Insecticide resistance comes of age (ffrench-Constant RH Genome Biology 2014, 15:106 (25 February 2014))

 

On Monday 17 we will have Carlos Villar, from Bruker, to give us an introduction to the use of the FTIR spectrometer Tensor-27. It will take about 3 hours, and he will bring a liquid cell and an ATR setup.

 

The Tensor-27 spectrometer is part of the biophysics lab of use for the IQFR members, located at room 324.

brukerFTIR

 

We will have a get-together to give our farewell to Isabel Cabo as manager of the Institute. It will take place at the hall in front of room 300 at 13:00-13:30. 

“How do pneumococci and other bacteria subvert the function of human proteins”

Friday 29th, 12:00

Room 300

Magnetic Properties Across Metal to Insulator Transitions

Room 300, Friday 10th January, 10:30

streptococcus pneumoniaeThe respiratory pathogen Streptococcus pneumoniae has evolved efficient mechanisms to resist oxidative stress conditions and to displace other bacteria in the nasopharynx. Here we characterize at physiological, functional and structural levels two novel surface-exposed thioredoxin-family lipoproteins, Etrx1 and Etrx2. The impact of both Etrx proteins and their redox partner methionine sulfoxide reductase SpMsrAB2 on pneumococcal pathogenesis was assessed in mouse virulence studies and phagocytosis assays. The results demonstrate that loss of function of either both Etrx proteins or SpMsrAB2 dramatically attenuated pneumococcal virulence in the acute mouse pneumonia model and that Etrx proteins compensate each other. The deficiency of Etrx proteins or SpMsrAB2 further enhanced bacterial uptake by macrophages, and accelerated pneumococcal killing by H2O2 or free methionine sulfoxides (MetSO). Moreover, the absence of both Etrx redox pathways provokes an accumulation of oxidized SpMsrAB2 in vivo. Taken together our results reveal insights into the role of two extracellular electron pathways required for reduction of SpMsrAB2 and surface-exposed MetSO. Identification of this system and its target proteins paves the way for the design of novel antimicrobials.

Reference:
Malek Saleh, Sergio G. Bartual, Mohammed R. Abdullah, Inga Jensch, Tauseef M. Asmat, Lothar Petruschka, Thomas Pribyl, Juan A. Hermoso* and Sven Hammerschmidt*
Molecular architecture of Streptococcus pneumoniae surface thioredoxin-fold lipoproteins crucial for extracellular oxidative stress resistance and maintenance of virulence
EMBO Molecular Medicine (2013) 5, 1852-1870  (doi:10.1002/emmm.201202435)

Referencia:

Malek Saleh, Sergio G. Bartual, Mohammed R. Abdullah, Inga Jensch, Tauseef M. Asmat, Lothar Petruschka, Thomas Pribyl, Juan A. Hermoso* and Sven Hammerschmidt*

Molecular architecture of Streptococcus pneumoniae surface thioredoxin-fold lipoproteins crucial for extracellular oxidative stress resistance and maintenance of virulence

EMBO Molecular Medicine (2013) 5, 1852-1870  (doi:10.1002/emmm.201202435)

We will have the traditional yearly meeting to briefly review 2013 at the main conference rooma t 13:00 and an informal lunch afterwards.